Dose Botulinum Toxin-a Induce Apoptosis in Rat Detrusor Muscle?
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چکیده
Hypothesis / aims of study In recent years there has been an increasing use of botulinum toxin-A (BTX-A) for treatment of detrusor overactivity [1]. In contrast, intraprostatic injection of BTX-A has been demonstrated to cause apoptosis in the prostate in humans and in animals [2]. However, the apoptotic action of BTX-A on the detrusor muscle, which could possibly induce atrophy of the bladder, is as of yet unknown. The aim of this study was to examine BTX-A-induced apoptosis in the detrusor muscle in male rats.
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Intravesical resiniferatoxin versus botulinum-A toxin injections for neurogenic detrusor overactivity: a prospective randomized study.
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